Endocrine Abstracts

The endocrine active compound 4-methylbenzylidene-camphor (4-MBC) is frequently used as an UV absorber in sunscreens and various skin care products. Though 4-MBC is weakly estrogenic in the reproductive system of fishes and rodents it shows strong anti-osteoporotic effects. Furthermore, different studies show percutanous absorption of 4-MBC after dermal administration resulting in identical biotransformation in humans and rats. Female Sprague-Dawley rats received five concentr...

Retinoic acid (RA) acts as an anti-proliferative and re-differentiation agent in the therapy of thyroid carcinoma but the molecular mechanisms by which RA mediates these effects are not well understood. We have investigated the effect of RA on the production and post-translational modification of the two ENO1 transcriptional products in the human follicular thyroid carcinoma cell line FTC-133. The single ENO1 transcript encodes a 48 kDa ENO1 with its unique N-terminal enolase ...